No, this comic is more about how weird the additions and changes to a franchise's canon can get when they are adapted to different mediums. I've never even watched any of the Indiana Jones movies, but I anticipated that if I didn't add that line in my picture description, lots of people would be making Kingdom of the Crystal Skull jokes.
Well I know he faved this picture here, so there's a chance he is a brony. Or at the very least, he likes the concept of bronies; older males who aren't afraid to admit they un-ironically enjoy a show about candy-colored ponies.
Not really, though I had anticipated KOTCS jokes way before I posted this (read the description). It's really more poking fun at adaptions between mediums, and how some of them are notorious for changing and adding/removing so many different ideas that they barely resemble the source material and often suffer from it. Take for example; the Cat in the Hat movie.